A research published in The Journal Of Science Translational Medicine indicates that a chemical “Resveratrol” found in red grapes can prevent bowel cancer in mice. The trial revealed that smaller doses of this chemical show a better result than larger doses.
Red grape dose and its outcome
Previously researchers believed that higher doses of resveratrol prevent cancer more effectively, and studies were conducted with that assumption. However, a new study compared the effects of resveratrol at a dose equivalent to the amount present in a 250ml glass of red wine with those of 200 times higher dose.
The study subjects were mice having bowel tumor with a potential to convert into cancer. An interesting observation of the study was mice receiving low dose resveratrol demonstrated 50% reduction in tumor size while larger dose caused only 25% reduction. So, it was concluded that resveratrol at a low dose can reverse tumor growth more effectively than higher doses.
Cancer inhibiting role of resveratrol in red grape
The trial was conducted on animals that were given high-fat diet. It was noted that only a small dose of resveratrol is needed to enter cancer cells and inhibit their cell division process. Higher doses have no added benefit over this mechanism.
Resveratrol is a naturally occurring chemical and most abundant in red grapes, grape skins and other fruits. Studies conducted on both animal and human suggest that it has anticancer effects. It has been suggested that resveratrol can play an effective role in cancer prevention in susceptible people. Bowel cancer occurs when a person having genetic susceptibility is exposed to environmental triggers like certain food or chemical.
According to Dr. Julie Sharp, the head of health information in UK cancer research, red wine is ineffective in preventing bowel cancer because resveratrol does not exist in free form in red wine. Rather, the alcohol content of the red wine increases the risk of cancer development in various organs of the body.
According to the statement of Karen Brown, a professor of translational cancer research, the beneficial role of lower doses of resveratrol is observed for the first time.
He suggested that other plant-derived chemicals and vitamins may also be studied to see if they have any cancer preventive role. More evidence should be gathered by conducting human trials to establish the anticancer effects of resveratrol.
What’s in the future?
There is still a lot to be learned about resveratrol when it comes to bowel cancer prevention. This study may serve as the basis for the further experiment on resveratrol. However, there is no alternative to a healthy and balanced diet containing vitamins, minerals, and fiber in appropriate proportion and quantity to lead a disease-free life. Red and processed meat, which is a risk factor for cancer development should be avoided.
(Source)
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